Gene information
Official symbol LTA
Official full name lymphotoxin alpha
Gene type protein-coding gene
Chromosome6p21.33
Alias symbolTNFSF1; LT
Previous symbolTNFB
Gene familyTumor necrosis factor superfamily
Resources
Entrez Gene 4049
HGNC HGNC:6709
Ensembl ENSG00000226979
Vega OTTHUMG00000031135
UCSC uc011ioe.3
GO terms: 45 records
GO Description Category LogP Number of genes Detail
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002676 regulation of chronic inflammatory response GO Biological Processes -7.26236298 5 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002712 regulation of B cell mediated immunity GO Biological Processes -6.15575915 8 More
GO:0002714 positive regulation of B cell mediated immunity GO Biological Processes -6.30679788 7 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002861 regulation of inflammatory response to antigenic stimulus GO Biological Processes -5.72585157 11 More
GO:0002863 positive regulation of inflammatory response to antigenic stimulus GO Biological Processes -5.04969016 4 More
GO:0002874 regulation of chronic inflammatory response to antigenic stimulus GO Biological Processes -5.78189015 3 More
GO:0002889 regulation of immunoglobulin mediated immune response GO Biological Processes -6.15575915 8 More
GO:0002891 positive regulation of immunoglobulin mediated immune response GO Biological Processes -6.30679788 7 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0014015 positive regulation of gliogenesis GO Biological Processes -11.0528361 19 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032729 positive regulation of interferon-gamma production GO Biological Processes -7.58110530 10 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0048145 regulation of fibroblast proliferation GO Biological Processes -11.1167439 21 More
GO:0048147 negative regulation of fibroblast proliferation GO Biological Processes -4.61361828 8 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0060251 regulation of glial cell proliferation GO Biological Processes -8.90876897 12 More
GO:0060252 positive regulation of glial cell proliferation GO Biological Processes -5.51502780 7 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
Drug-Gene interaction
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Related drugs: 4 records
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
NM_000595.4:c.-10+90A>G genomics myocardial infarction[diagnosis] myocardial infarction Ozaki K et al. Nat Genet. 2002
NM_000595.4:c.-10+90A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Mizuno H et al. Atherosclerosis. 2006
NM_000595.4:c.-10+90A>G genomics myocardial infarction[diagnosis] myocardial infarction Koch W et al. Hum Mol Genet. 2007
NM_000595.4:c.-162G>A genomics myocardial infarction[diagnosis] myocardial infarction Koch W et al. Hum Mol Genet. 2007
NM_000595.4:c.179C>A genomics myocardial infarction[diagnosis] myocardial infarction Koch W et al. Hum Mol Genet. 2007
NM_000595.4:c.-10+90A>G genomics myocardial infarction[diagnosis] myocardial infarction Panoulas VF et al. Ann Rheum Dis. 2008
NM_000595.4:c.-10+90A>G genomics adverse events[prognosis (bad)] myocardial infarction Sukhinina TS et al. Kardiologiia. 2012
NM_000595.4:c.179C>A genomics death[prognosis (bad)] acute myocardial infarction Suna S et al. Atherosclerosis. 2013
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